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Search Results for " cardiac fibroblasts "

8

Compounds

Cat No. Product Name Synonyms Targets
T0267 Zonisamide AD 810,CI 912 Calcium Channel , Sodium Channel , Carbonic Anhydrase
Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms...
T8366 Mitochonic acid 5 MA-5 Mitochondrial Metabolism
Mitochonic acid 5 (MA-5) is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of f...
TP1904L FSLLRY-NH2 TFA(245329-02-6 free base) Protease-activated Receptor
FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in iso...
T10409 ATX inhibitor 5 PDE
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50 : 15.3 nM) that reduces the level of CCl4-induced hepatic fibrosis and has anti-hepatic fibrosis effects,.
TP1904 FSLLRY-NH2
Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduce...
T63820 DCN1-UBC12-IN-2
DCN1-UBC12-IN-2 is a potent, specific DCN1-UBC12 inhibitor with an IC50 value of 9.55 nM. DCN1-UBC12-IN-2 specifically targets DCN1-UBC12 interactions and slows Ang II-induced activation of cardiac fibroblasts.
T60713 TK-129
TK-129 is an orally active, potent inhibitor of KDM5B with IC 50 of 44 nM that is low-toxicity. TK-129 shows cardioprotective effects by inhibiting KDM5B and blocking the KDM5B -associated Wnt pathway. TK-129 can be used...
T83766 Moexiprilat RS 10029
Moexiprilat, an active metabolite of the prodrug moexipril formed through side chain ester hydrolysis in vivo, functions as an angiotensin-converting enzyme (ACE; IC50 = 2.1 nM) inhibitor. At a concentration of 10 nM, it...
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