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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0267 | Zonisamide | AD 810,CI 912 | Calcium Channel , Sodium Channel , Carbonic Anhydrase |
Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms... | |||
T8366 | Mitochonic acid 5 | MA-5 | Mitochondrial Metabolism |
Mitochonic acid 5 (MA-5) is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of f... | |||
TP1904L | FSLLRY-NH2 TFA(245329-02-6 free base) | Protease-activated Receptor | |
FSLLRY-NH2 TFA is a is a protease-activated receptor 2 (PAR2) inhibitor. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in iso... | |||
T10409 | ATX inhibitor 5 | PDE | |
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50 : 15.3 nM) that reduces the level of CCl4-induced hepatic fibrosis and has anti-hepatic fibrosis effects,. | |||
TP1904 | FSLLRY-NH2 | ||
Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduce... | |||
T63820 | DCN1-UBC12-IN-2 | ||
DCN1-UBC12-IN-2 is a potent, specific DCN1-UBC12 inhibitor with an IC50 value of 9.55 nM. DCN1-UBC12-IN-2 specifically targets DCN1-UBC12 interactions and slows Ang II-induced activation of cardiac fibroblasts. | |||
T60713 | TK-129 | ||
TK-129 is an orally active, potent inhibitor of KDM5B with IC 50 of 44 nM that is low-toxicity. TK-129 shows cardioprotective effects by inhibiting KDM5B and blocking the KDM5B -associated Wnt pathway. TK-129 can be used... | |||
T83766 | Moexiprilat | RS 10029 | |
Moexiprilat, an active metabolite of the prodrug moexipril formed through side chain ester hydrolysis in vivo, functions as an angiotensin-converting enzyme (ACE; IC50 = 2.1 nM) inhibitor. At a concentration of 10 nM, it... |